cholesterol CAS ：57-88-5

Common Name cholesterol
CAS Number 57-88-5
Molecular Weight 386.654
Density 1.0±0.1 g/cm3
Boiling Point 360 ºC
Molecular Formula C27H46O
Melting Point 148-150 °C

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Product Introduction

Use of cholesterol

Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated. IC50 value:Target:In vitro: GT1-7 hypothalamic cells subjected to cholesterol depletion in vitro produced 20-31% reductions in cellular cholesterol content, similar to the decrease in cholesterol synthesis observed in diabetes [1].In vivo:

Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	cholesterol
Synonym	More Synonyms

cholesterol Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated. IC50 value:Target:In vitro: GT1-7 hypothalamic cells subjected to cholesterol depletion in vitro produced 20-31% reductions in cellular cholesterol content, similar to the decrease in cholesterol synthesis observed in diabetes [1].In vivo:
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Others Natural Products >> Steroids
Target	Human Endogenous Metabolite
References	[1]. Laverdy OG, et al. Effects of glycemic control upon serum lipids and lipid transfers to HDL in patients with type 2 diabetes mellitus: novel findings in unesterified cholesterol status. Experimental and Clinical Endocrinology & Diabetes, 2015, 123(4):232-239 [2]. Sandy Huey-Jen Hsu, et al. Validation of the Estimation of Low-density LipoproteinCholesterol by the Modified Friedewald Equation in EthnicChinese Adults Living in Taiwan. Internal Medicine, 54: 2291-2297, 2015 [3]. Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14.

Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.0±0.1 g/cm3
Boiling Point	360 ºC
Melting Point	148-150 °C
Molecular Formula	C27H46O
Molecular Weight	386.654
Flash Point	250 ºC
Exact Mass	386.354858
PSA	20.23000
LogP	9.85
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.525
InChIKey	HVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES	CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C
Water Solubility	negligible

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