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Diosgenin CAS 512-04-9

  • Diosgenin CAS 512-04-9

Diosgenin CAS 512-04-9

Common Name Diosgenin
CAS Number 512-04-9
Molecular Weight 414.621
Density 1.1±0.1 g/cm3
Boiling Point 527.1±50.0 °C at 760 mmHg
Molecular Formula C27H42O3
Melting Point 205-208°C
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Product Introduction

Summary: Diosgenin, also known as diosgenin, has a molecular formula of C27H42O3 and a molecular weight of 414.621. It appears as plate-like or needle-like crystals with a melting point of 205-208°C and a density of 1.1±0.1 g/cm3. Primarily used as a precursor for synthesizing steroid hormones such as hydrocortisone. For research-use only, not for medical or clinical usage.

    Chemical & Physical Properties

    This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

    Density1.1±0.1 g/cm3
    Boiling Point527.1±50.0 °C at 760 mmHg
    Melting Point205-208°C
    Molecular FormulaC27H42O3
    Molecular Weight414.621
    Flash Point272.6±30.1 °C
    Exact Mass414.313385
    PSA38.69000
    LogP5.84
    Vapour Pressure0.0±3.1 mmHg at 25°C
    Index of Refraction1.564
    InChIKeyWQLVFSAGQJTQCK-VKROHFNGSA-N
    SMILESCC1CCC2(OC1)OC1CC3C4CC=C5CC(O)CCC5(C)C4CCC3(C)C1C2C
    Storage conditionRefrigerator
    Water Solubilitychloroform: 20 mg/mL, clear, slightly yellow
    DescriptionDiosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway.
    Related Catalog
    Target

    STAT3

    In VitroIn MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 μM, may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[1]. Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibition occurring at around 100 μM[2].
    In VivoDiosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenin treatment significantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice[3].
    References

    [1]. Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin asmultifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324–7331

    [2]. Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207.

    [3]. Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):286-96.


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