Cholic acid CAS: 81-25-4

Chinese Name    Cholic acid

English Name    Cholic acid

Alias    Cholic acid

Cholic acid Source: Cattle and sheep

Ursodeoxycholic acid EP Impurity B

3α,7α,12α-Trihydroxy-5β-cholanic acid

CAS    81-25-4

EINECS    201-337-8

Chemical Formula    C24H40O5

Molecular Weight    408.58

InChI InChI=1/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19 (22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14?,15+,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1

InChI Key    BHQCQFFYRZLCQQ-OELDTZBJSA-N

Density    1.0310 (rough estimate)

Melting point    200–201 °C (lit.)

Boiling point 449.08 °C (rough estimate)

Specific Rotation    36 º (c=0.6, 95% EtOH)

Flash Point    9 °C

Water Solubility    0.28 g/L (15 °C)

Vapor Pressure    4.59E-16 mmHg at 25 °C

Solubility Methanol: 0.1 g/mL, clear

Refractive Index    1.5800 (estimate)

Acidity Coefficient    4.98 (at 20 °C)

Storage Conditions    2–8 °C

Sensitivity    Easily absorbs moisture

Appearance    Clean

Color    White to brown

Merck    14,2203

BRN    2822009

Physical and Chemical Properties    This substance is found in the bile of cattle, sheep, and pigs. It appears as colorless flakes or a white crystalline powder. It has a slightly bitter taste, followed by a slightly sweet aftertaste. Mp 198°C; specific rotation (c = 0.6, ethanol) is +37°. 1 g of cholic acid is approximately soluble in 300 mL of ethanol or acetone, 7 mL of glacial acetic acid, and sparingly soluble in water. The monohydrate is a white, flaky crystal. In 1927, H. Wieland (Germany) was awarded the Nobel Prize in Chemistry for his research on the composition of cholic acid.

Product Application    An organic acid with a steroid structure that emulsifies fats and promotes their digestion.

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